
Adenosine amine congener
CAS No. 96760-69-9
Adenosine amine congener ( ADAC )
Catalog No. M21004 CAS No. 96760-69-9
Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.
Purity : >98% (HPLC)






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5MG | 147 | Get Quote |
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10MG | 222 | Get Quote |
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25MG | 402 | Get Quote |
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50MG | 593 | Get Quote |
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100MG | 845 | Get Quote |
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Biological Information
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Product NameAdenosine amine congener
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NoteResearch use only, not for human use.
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Brief DescriptionAdenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.
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DescriptionAdenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.
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In VitroAdenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways.
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In VivoAdenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner. Animal Model:Male Wistar rats (8-10 weeks old) treated with noise exposure Dosage:25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day Administration:Intraperitoneal injection; daily; for 5 days Result:Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).
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SynonymsADAC
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA1
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Research Area——
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Indication——
Chemical Information
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CAS Number96760-69-9
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Formula Weight576.6
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Molecular FormulaC28H32N8O6
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (54.20 mM)
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SMILESNCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4c3ncn4C3OC(CO)C(O)C3O)cc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vlajkovic S M Lee K H Wong A C Y et al. Adenosine amine congener mitigates noise-induced cochlear injury[J]. Purinergic Signalling 2010 6(2):p.273-281.
molnova catalog



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