Adenosine amine congener

CAS No. 96760-69-9

Adenosine amine congener ( ADAC )

Catalog No. M21004 CAS No. 96760-69-9

Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 Get Quote
10MG 222 Get Quote
25MG 402 Get Quote
50MG 593 Get Quote
100MG 845 Get Quote
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Biological Information

  • Product Name
    Adenosine amine congener
  • Note
    Research use only, not for human use.
  • Brief Description
    Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.
  • Description
    Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.
  • In Vitro
    Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways.
  • In Vivo
    Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner. Animal Model:Male Wistar rats (8-10 weeks old) treated with noise exposure Dosage:25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day Administration:Intraperitoneal injection; daily; for 5 days Result:Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).
  • Synonyms
    ADAC
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    96760-69-9
  • Formula Weight
    576.6
  • Molecular Formula
    C28H32N8O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (54.20 mM)
  • SMILES
    NCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4c3ncn4C3OC(CO)C(O)C3O)cc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vlajkovic S M Lee K H Wong A C Y et al. Adenosine amine congener mitigates noise-induced cochlear injury[J]. Purinergic Signalling 2010 6(2):p.273-281.
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